Protein Details: Protein orai

Protein ID

ICDB_Pro_0790

Protein Name

Protein orai

Gene Name

orai-1; C09F5.2

Organism

Caenorhabditis elegans

Length

293 amino acids

AlphaFoldDB

AF-Q09232-F1-model_v4.pdb

Function

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor; stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function.

Sequence

MPRSHDPSRVELLRKEGGLTEKRVSISVEDIRGAVANWKNSGGAGDPITPYPLPQFFLQPPSTAGGGSRNGVGSKEGSVTSLRMPLKKAGDDVDLGHRGELDLSEKYNYDLSRAQLKASSRTSALLAGFAMVCLVELQYDQSTPKPLLIVLGVVTSLLVSVHLLALMMSTCILPYMEATGCTQDSPHIKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVKFTAVGYPTAGYITTAMLVPVGVVFVVFSYLIHKNRVSHSLGRFKHKVDTMKQFLDVEANLQKSTLAPSTIRDI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in gonad sheath cells; hypodermis; intestine and spermatheca. Coexpressed with stim-1.

DOI ID

10.1126/science.282.5396.2012; 10.1016/j.ceca.2007.02.007; 10.1113/jphysiol.2006.124883

RefSeq

NP_001254834.1